igenify Panel

 

The igenify panel allows a prediction of person’s specific drug metabolism rate.  There are four types of drug metabolism:

  • Ultra rapid. The ultra rapid metabolism indicates a genotype that quickly metabolizes drugs. A person will have at least one version of the gene that is fast. This person may need a higher than typical dose.
  • Extensive. The extensive metabolism breaks down medicines at a normal rate. This means both copies of the gene are typical.
  • Intermediate. The intermediate metabolism is a slower than normal drug metabolism, indicating a person possesses one typical gene and one slow-working gene.
  • Poor. The poor metabolism is the slowest category of drug metabolism. A person with this genotype inherited two slow metabolizing versions of the gene. This person may experience an adverse effect of the drug and/or may need a lower dose or an alternative medication.

We use drug metabolism rate information to make recommendations for medicines that work best with your patient’s genetic make-up. Knowledge of how a patient is likely to respond to certain medicines can aid in avoiding side effects and finding the right treatment faster. The gene-drug pairs in our panel include:

Antidepressant Medications

Gene(s)Generic Drug Name
CYP2C19citalopram
CYP2C19sertraline
CYP2C19escitalopram
CY2D6duloxetine
CYP2D6aripiprazole
CYP2D6fluoxetine
CYP2D6paroxetine
CYP2D6amitriptyline
CYP2D6desipramine
CYP2D6atomoxetine
CYP2C19, CYP2D6doxepin
CYP2C19, CYP2D6clomipramine
CYP2C19, CYP2D6imipramine
CYP2C19, CYP2D6trimipramine
CYP2C19, CYP2D6fluvoxamine
CYP2C19, CYP2D6nortriptaline

Analgesic Medications

Gene(s)Generic Drug Name
CYP2D6codeine
CYP2D6oxycodone
CYP2D6tramadol

Other Medications

Gene(s)Generic Drug Name
HLA-Babacavir
TPMTazathioprine
TPMTmercaptopurine
CYP2C9, VKORC1, CYP4F2warfarin
CYP2D6metoprolol
CYP2D6tamoxifen
SLCO1B1simvastatin
CYP3A5tacrolimus
CYP2C19clopidogrel